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Category : Womens Health
Name of brand : Duphaston
Name of generic : Dydrogesterone
Title : Generic Duphaston (Dydrogesterone)
Short descriptions : Duphaston (Dydrogesterone) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.At therapeutic levels, dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, Duphaston is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol.
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Common uses

Duphaston is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, Duphaston has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, Duphaston is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol.

Before using

Irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency.

Combined with an estrogenic substance, Duphaston can be applied in secondary amenorrhoea, dysfunctional uterine bleeding and post-menopausal complaints where endogenous progesterone deficiency is implicated.

Directions

In general

The dosage schemes below are meant as general recommendations. For optimal therapeutic effect, the dosages are to be adapted to the nature and severity of the disorder.

In irregular cycles due to endogenous progesterone deficiency

Duphaston 5 to 10 mg is recommended especially in irregular cycles due to shortened luteal phase (ie pre-menopause). Treatment should be repeated for several cycles.

In secondary amenorrhoea

Administration of Duphaston in combination with an estrogen is usually recommended as in these conditions endogenous progesterone deficiency is nearly always accompanied by estrogen deficiency. 0,05 mg ethinylestradiol is administered each day from the 1st to the 25th day of the cycle, and 5 mg Duphaston is added twice daily from the 11th to the 25th day. Five days after the subsequent withdrawal bleeding, the same is repeated to imitate a natural cycle.

In dysfunctional uterine bleeding

The symptomatic treatment is aimed at stopping the bleeding and including a subsequent withdrawal bleeding.

To stop bleeding: Duphaston 10 mg together with 0,10 mg ethinylestradiol twice daily for 5 to 7 days.

To prevent heavy bleedings: Duphaston 5 mg twice daily from day 11 to day 25 of the cycle, if necessary, combined with an estrogen during the first half of the cycle.

In post-menopausal complaints

If for the symptomatic treatment of post-menopausal complaints estrogens are used (hormone replacement therapy — HRT), Duphaston 10 mg is used to counteract the effects of unopposed estrogens on the endometrium. A subsequent withdrawal bleeding is induced.

If on continuous estrogen therapy: Duphaston 10 mg twice daily during the first 12 to 14 days of each calendar month.

If on cyclic estrogen therapy: Duphaston 10 mg twice daily during the last 12 to 14 days of the treatment.

Cautions

Duphaston should not be given to patients with undiagnosed vaginal bleeding nor to those with a history of thromboembolic disorders.

Duphaston should be used with caution in patients with cardiovascular, renal or hepatic impairment, diabetes mellitus, asthma, epilepsy and migraine. It should be used with care in persons with a history of mental depression.

Store in a dry, dark place at temperatures not exceeding 25°C. Keep out of reach of children.

Possible side effects

Side effects of Duphaston may include gastro-intestinal disturbances, allergic skin rashes or urticaria, changes in libido, acne, fluid retention, mass gain, mental depression and breast changes, which may include discomfort or gynaecomastia. Alterations in liver function tests have been reported and less frequently jaundice.

In a small percentage of the treated cases, breakthrough bleeding may occur, which can be prevented by increasing the dosage. During the clinical application of Duphaston, no virilising side effects were observed.

If you take too much

See "Possible side effects" and "Cautions". Treatment is symptomatic and supportive.

Drug interactions

Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Some medicines or medical conditions may interact with this medicine. Inform your doctor or pharmacist of all prescription and over-the-counter medicine that you are taking.

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Rx Prescription Updates at Med Store

Modalert (Provigil) is used to improve wakefulness in patients with narcolepsy (sudden uncontrollable attacks of daytime sleepiness), obstructive sleep apnea/hypopnea syndrome, or in patients with shift work sleep disorder. 100mg 30 pills for $39.30
Combivir (Lamivudine / Zidovudine) is an antiviral combination used with other medicines to treat Human Immunodeficiency Virus (HIV) infection. 300mg/150mg 10 tabs for $28.76
Copegus (Ribavirin) is a nucleoside analog antiviral medicine that is used in combination with interferon to treat chronic hepatitis C infection. Hepatitis C is a viral infection that causes swelling or enlargement of the liver. 100mg 30 pills for $112.20
Ditropan (Oxybutynin) is an anticholinergic agent used to treat certain conditions of the bladder. 2.5mg 30 pills for $22.80
Epivir (Lamivudine) is a nucleoside analogue used with other medicines (such as zidovudine or ritonavir) to treat Human Immunodeficiency Virus infection (HIV). 150mg 30 pills for $38.63
Famvir (Famciclovir) is an antiviral used to treat herpes zoster (shingles) and genital herpes. It may also be used to treat other conditions as determined by your doctor. 250mg 10 pills for $34.81
Rebetol (Ribavirin) is a nucleoside analog antiviral medicine that is used in combination with interferon to treat chronic hepatitis C infection. Hepatitis C is a viral infection that causes swelling or enlargement of the liver. 100mg 30 pills for $102.60
Retrovir (Zidovudine) is an antiviral used to manage Human Immunodeficiency Virus infection (HIV). It is also used to prevent the transmission of HIV to the fetus during pregnancy. 100mg 30 caps for $26.71
Symmetrel (Amantadine) is used to prevent or treat the flu. It may also be used to treat symptoms of parkinson 100mg 30 pills for $18.64
Urispas (Flavoxate) is an anticholinergic agent used to treat bladder or bowel spasms and in combination with other medicines to treat ulcers. It may also be used to treat other conditions as determined by your doctor. 100mg 30 pills for $19.10
Valtrex (Valacyclovir) is an antiviral used in patients with normal immune systems to treat herpes zoster infections (shingles) or to treat or suppress genital herpes. This medicine may be used in combination with safe sex practices in patients with genital herpes to help reduce the risk of spreading the condition to others. This medicine may also be used for cold sores (herpes simplex) or other conditions as determined by your doctor. 500mg 20 pills for $50.60
Videx (Didanosine) is a nucleoside analog reverse transcriptase inhibitor (NRTI) used in combination with other medicines to manage HIV infection. 100mg 30 caps for $66.00
Viramune (Nevirapine) is a non-nucleoside reverse transcriptase inhibitor used to treat Human Immunodeficiency Virus infection (HIV). This medicine is not a cure for HIV. It must be used in combination with other proven anti-HIV medicines. If this medicine is taken alone to treat HIV infection, it may stop working. Contact your doctor for more information. It may also be used to treat other conditions as determined by your doctor. 200mg 30 tabs for $48.10
Zerit (Stavudine) is a nucleoside analogue antiviral used in combination with other medicines to manage Human Immunodeficiency Virus (HIV) infection. 30mg 30 caps for $31.80
Zovirax (Acyclovir) is an antiviral used to treat shingles, chickenpox, or genital herpes. It may also be used to treat other conditions as determined by your doctor. 200mg 30 pills for $24.53
Amoxicillin is a penicillin antibiotic used to treat bacterial infections. 500mg 30 pills for $24.78
Ampicillin is a penicillin antibiotic used to treat bacterial infections. 250mg 100 pills for $43.00
Augmentin (Amoxicillin / Clavulanate) is a penicillin antibiotic used to treat bacterial infections. 375mg 5 pills for $18.94
Bactrim (Sulfamethoxazole / Trimethoprim) is an antibiotic combination used to treat or prevent infections. 480mg 90 pills for $27.60
Biaxin (Clarithromycin) is a macrolide antibiotic used to treat bacterial infections. 250mg 30 pills for $66.00
Ceclor (Cefaclor) is a cephalosporin antibiotic used to treat bacterial infections. This medicine will not treat infections caused by viruses. 250mg 10 caps for $20.78
Ceftin (Cefuroxime) is prescribed for mild to moderately severe bacterial infections of the throat, lungs, ears, skin, sinuses, and urinary tract, and for gonorrhea. 125mg 30 pills for $50.10
Chloromycetin (Chloramphenicol) is an antibiotic used to treat eye infections. 250mg 60 caps for $34.60
Cipro (Ciprofloxacin) is a fluoroquinolone antibiotic used to treat bacterial infections. 250mg 30 pills for $26.64
Cleocin (Clindamycin) is a lincomycin antibiotic used to treat bacterial infections. 150mg 30 caps for $28.69
Generic Doxycycline (Doxycycline Hyclate) is a tetracycline antibiotic used to treat bacterial infections. This medicine is not effective treating infections caused by viruses. 100mg 60 tabs for $29.40
Duricef (Cefadroxil) is a cephalosporin antibiotic used to treat bacterial infections. This medicine will not treat infections caused by viruses. 250mg 30 caps for $18.92
Floxin (Ofloxacin) is a fluoroquinolone antibiotic used to treat bacterial infections. 100mg 10 pills for $18.94
Ilosone (Erythromycin) is an antibiotic used to treat acne. 500mg 90 pills for $44.10
Keflex (Cephalexin) is a cephalosporin antibiotic used to treat bacterial infections. This medicine will not treat infections caused by viruses. 250mg 40 pills for $38.40

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